What are the connotations of the words "Af Ani"?
Rashi: It means that Hashem will deal with us with anger.
Seforno: I will do what you wanted to do, inasmuch as the covenant will be annulled from My part as well. 3
In the way that He punished Sancheriv (See R.Chavel's footnotes),
Ramban: That is why the Torah inserts the word "Ani" throughout the current Parshah - "Vehalchti Af Ani" (Pasuk 24), "Vehikeisi eschem Gam Ani" (Ibid.), "Veyisari eschem Af Ani" (Pasuk 28), "Vahashimosi Ani " (Pasuk 32) and "Af Ani Eilech imachem" (Pasuk 41). Refer also to 26:15:3:3*
What does "Vehifkadti" mean?
Rashi #1: It means 'I will command'. 1
Rashi #2 (on Pasuk 17): It means 'I will visit upon you one plague after another'.
See Sifsei Chachamim.
What is the meaning of "Vehifkadti aleichem Behalah" mean?
Rashi: It means 'I will command on you a plague that causes shock, Makas Mosan. 1
Seforno: It means that Hashem will appoint officers of shock. 2
What is the difference between "Shachefes" and "Kadachas"?
Rashi: "Shachefes" means 'swelling', 1 "Kadachas", a high fever.
Rashi: Where the swelling has subsided, but the flesh remains sickly-looking.
What does theTorah mean when it writes "Mechalos Einayim u'Medivos Nafesh"?
Rashi: It means that the 'eyes' long for the plague to heal, and when the patient dies, they are bitterly disappointed.
If one plants in vain, how can the enemy eat the crops that grow?
Rashi #1: The Pasuk means that, even on the off-chance that something does grow, the enemy will eat it.
Rashi #2: The first year you will sow, but nothing will grow. The second year, you will sow and the crops will grow, but the enemy will take them to feed their troops during the siege, whilst you starve in the towns.
Rashi #3: "u'Zeratem la'Rik Kochachem" refers to the children that you will rear in vain, because, due to your sins, the enemy will kill them. 1
Targum Yonasan: What the enemy will eat is the Sefichim, that grow wild.
What is the difference between the current K'lalos and the K'lalos in Ki Savo?
Ramban: The current K'lalos hint at the first Galus (Galus Bavel), 1 which were the result of the abrogation of the B'ris 2 that Hashem made by His Great Name. 3 whereas those in Ki Savo 4 are said in the third person." 5 And this also explains why the Torah refers here to "Alos ha'Beris," whereas in Ki Savo, it uses the Lashon "Arur" - since they devoid of Berachah.
See Ramban, who cites a number of proofs that the current Parshah is hinting at the era of the first Beis Hamikdash and Galus Bavel, and that of Ki Savo, at the era of the second Beis-Hamikdash and Galus Edom.
Ramban: As indicated later in Pasuk 46.
Which hint at the second Churban, which was not connected to the current B'ris, which was no longer in effect.
Ramban: See Devarim 28:15. Hence the Gemara states in Megilah, 31b 'The curses in Toras Kohanim were said in the plural and Moshe presented them in the Name of Hashem; whereas those in Mishneh Torah were said in the singular and Moshe (whom Hashem appointed as His Shali'ach - Ramban), presented them in His own name.