1)
What should the Pesayim abandon?
1.
Rashi: The way of folly. Malbim - he abandons it via eating the bread of Chachmah.
2)
What is the meaning of "v'Ishru"?
1.
Rashi: It is an expression of a step, like "ba'Ashuro Achazah Ragli" (Iyov 23:11).
2.
Malbim: You will have happiness [of the Nefesh via contemplating the depth of words of Chachmah. You will veer from the Yetzer of desire, to happiness and good.