Why does it say "Chai Ani"?
Malbim: This is to put a Shevu'ah on the decree.
How were they Metamei the Mikdash?
Radak: Menasheh put an image of the Asherah in the Mikdash.
Why does it say "b'Chol Shikutzayich" and "uv'Chol To'avosayich"?
Malbim: The former is putting idols in the Heichal. The latter is other abomination mentioned below (Perek 20).
What is the meaning of "Gam Ani Egra"?
Radak: Just like you reduced My honor via putting abominations [in My Mikdash], I will reduce your honor, and you will be disgraced in the eyes of strangers, and they will do judgments to you.
Malbim: Aside from what the hunger and enemy will diminish you, I will add to diminish you.
Why does it say "Gam Ani Lo Echmol"?
Radak: Just like you did not have mercy on My honor, not to profane it.