What is the meaning of the first half of the Pasuk?
Targum Onkelos: It means literally 'You will grope in the middle of the day (when there is plenty of sunlight) like a blind man gropes in darkness'.
Targum Yonasan: It means that you will seek advice to ease your problems ... but there is no-one to give you advice that is correct.
Why does the Torah insert the word 'ba'Afeilah"? What difference does it make to a blind man whether it is the middle of the day or the midle of the night?
Megilah, 24b: Because, whenever a blind man walks in the night holding a lamp, people will come and assist him to find his way. 1
As R. Yossi learned from a blind man whom he found carrying lamp at night. See Megilah, Ibid.
What is the meaning of "Ashuk"?
Rashi: It means that people will contest the legality of everything that you do. 1
Ibn Ezra: It means that others will take away your wife, house, vineyard and ox - as the following Pesukim go on to explain.?
Alshich (citing Yalkut Shimoni Esther, 1056): It refers to Galus Madai, where they did not suffer illnesses or death, only the Nochrim taunted them, constantly threatening that they would kill them tomorrow!
Sifsei Chachamim: It cannot mean withholding wages or Gezel, which have already been mentioned. Therefore, Rashi explains it like the Pasuk in Toldos Bereishis, 26:20 "Shem ha'Be'er Eisek ki His'asku Imo."
