1)
What is the significance of disgracing His Kodshim?
1.
Rashi: This is the opposite of "li'Rtzonchem Tizbachuhu" (Vayikra 19:5).
2.
Radak: "V'Haveisem Gazul v'Es ha'Pise'ach v'Es ha'Choleh" (Mal'achi 1:13).
3.
Malbim: There is Kodesh in the world, year, and Nefesh. Kodesh in the Nefesh are parents and Nesi'im; it already said that they disgraced these Kedoshim (6-7). Kodesh in the world is Kodshim of Hekdesh and the Mikdash ? "Kodashai Bazis." Also refer to 22:8:2:2.
2)
Why does it mention Chilul Shabbos?
1.
Radak: We find that Yirmeyah warned them about Chilul Shabbos.
2.
Malbim: There is Kodesh in the year ? Shabbos and Yamim Tovim; they profaned them.