1)
What is the question "Anah Elech me'Ruchacha"?
1.
Radak: "Anah" is like An (where). Man cannot go if Ru'ach Hashem will not lead him. "Me'Ruchacha" is like mi'Panecha. If I will think to hide or flee from You, where can I go?! You are found everywhere. Place does not contain You!
2.
Malbim: How can I go from the fortress in which I am? Where will I find a path to go from Your Ru'ach, and leave the siege?
2)
What is the question "v'Anah mi'Panecha Evrach"?
1.
Radak: The matter is repeated in different words.
2.
Malbim: Even if I could leave the siege, where can I flee and not be under Your authority?!