1)
What is the Siman?
1.
Radak: When you will see soon Nebuchadnetzar come to Pharaoh, like I prophesized for you, you will know that you will be finished off in Egypt.
2.
Malbim: If Nebuchadnetzar would conquer Melech Egypt in war outside of Egypt, he would not eradicate the residents of the country.
2)
Why does it say "Kom" with a Cholem?
1.
Radak: This is Makor (like an infinitive), like "v'Shov Elai" (Yehoshua 18:8).