Which yoke will Hashem break?
Rashi: It is the yoke of nations on Yisrael.
Radak #1: It is the yoke of Gog and Magog.
Radak #2: It is the yoke of every nation that put a yoke on Yisrael in exile. Yonason translates like this.
Malbim: It is the yoke of Bavel, i.e. heavy tax and servitude.
After breaking the yoke, what is the significance of uprooting "Moserosecha"?
Malbim: Sometimes a yoke is broken, and they are still in the straps of servitude, for they are [still] under the kingdom, like they were under Koresh, without a heavy yoke. Hashem will break also this, and they will not serve strangers again.
Why does it say "Tzavarecha u'Moserosecha" (second person), and "Vo" (third person)?
Radak: Verses sometimes switch between second and third person.