1)
What is the significance of that it was ruined?
1.
Malbim: There is no longer a solution for Yisrael.
2)
What is the meaning of "Lo Yitzlach la'Kol"?
1.
Rashi: It is not proper for anything. Radak - this is like "Kol Melachah Lo Sa'asu" (Vayikra 23:3) - any Melachah. "Kol Chelev v'Chol Dam" (Vayikra 3:17) - any Chelev or blood.