1)
What is "me'Chamas Achicha Yakov"?
1.
Rashi: Due to the injustice that you did to Yakov. Malbim - due to this, you will be covered with shame in the past Churbanos, and in the end you will be cut off permanently in the future Churban, which is eternal.
2.
Radak: In Churban Bayis Sheni, the Edomim did evil to Yisrael. The Navi prophesized that they will do evil to Yisrael, and Hashem will pay (punish) them at the end of days; He will eradicate them from the world.
3.
Radak citing Ibn Ezra: This refers to Churban Bayis Rishon; Bnei Edom did evil to Yisrael in their exile via Nebuchadnetzar.
