1)
What is "Holelim"?
1.
Rashi: It is people acting madly.
2.
Rashi citing Shocher Tov 8: It is mixed up.
3.
Radak: Sometimes it is folly, like "va'Yis'halelu b'Yadam" (Shmuel I, 21:14), "Amarti Meholal" (Koheles 2:2). Sometimes it is evil - "Holelus Ra'ah" (ibid., 10:13) and similar verses.
2)
Why does it say "Lo Yis'yatzvu Holelim l'Neged Eineicha"?
1.
Radak: This is like the verse concludes - You hate all who do evil. One who hates someone does not want to see him.
2.
Malbim: This is unlike the nations. Holelim stand up to resemble their gods, cruel murderers like themselves.