1)
How did Hashem destroy him?
1.
Malbim: He killed his children around him.
2)
What is the meaning of "va'Yasa ka'Etz Tikvasi"?
1.
Rashi: Va'Yasa is an expression of uprooting. Ibn Ezra - He uprooted my hope like a tree is moved from its place.
2.
Malbim: Just like one uproots a tree from its roots, so He uprooted my hope with the root, i.e. afflicted my body with pains that have no cure.


