What is the significance of Hashem's anger?
Rashi (in Sotah, 47b) Perversion of justice always brings about Hashem's anger.
Seforno: Whenever a victim cries out in anguish, Hashem has compassion on the victim and displays anger towards the oppressor.
What are the ramifications of the Charon Af of Hashem?
Mechilta: Based on the Gezeirah Shavah "Vecherah Apo" "Vecharah Af Hashem" in the second Parshah of the Sh'ma, it results in a shortage of rain and Galus. 1
Oznayim la'Torah #1, citing the Eliyahu Rabah: When R. Shimon ben Gamliel asked Yochanan Kohen Gadol why they were being killed like Mechal'lei Shabbos, Ovdei Avodah Zarah and Megalei Arayos, he replied that it was perhaps because they indulged in food and drink, and when Almanos and Yesomim came to them for help, they did nothing to alleviate their suffering
Having stated "Veharagti eschem", why does the Torah see fit to add "Vehayu Nesheichem Almanos ... "?
Rashi: Not only will your wives become widows and your sons orphans, but, since there will be no witnesses to testify on your death, 1 your wives will be Agunos (unable to remarry) and your sons, unable to claim their inheritance.
Meshech Chochmah: You will be killed via the sword, i.e. the kingdom (they kill only via a sword - Yerushalmi Sanhedrin 6:1). In such a case, the kingdom takes your money, and your widow will not get her Kesuvah and your children will not inherit.
And nobody will know whether you died or were taken captive (Rashi).
Why does the Torah not simply write 'Mos Tamus', like it does by other Chayvei Misos bi'Yedei Shamayim?
Ramban: Because, unlike other cases of Misah bi'Yedei Shamayim 1 (which is synonymous with Dever - pestilence), someone who afflicts a widow or an orphan will die by the sword or simply disappear without trace in battle. 2
What is the significance of the punishment?